Endo Battery Fast Charged Ep. 9

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Endo Battery Fast Charged Ep. 9
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Explore all the facinating and insightful research that’s helping us understand Endometriosis and all it’s nuances. 
This episode we cover the following studies:

1.)The causal relationship of depression, anxiety, and neuroticism with endometriosis: A bidirectional 2-sample Mendelian randomization study. Medicine (Baltimore). 2024 Jul 12;103(28):e38823. 

2.) Mental illness and sleep disorders among women with gynecological problems. J Psychosom Obstet Gynaecol. 2024 Dec;45(1):2354330. 

3.)The impact of surgical treatment for deep endometriosis: metabolic profile, quality of life and psychological aspects. Rev Bras Ginecol Obstet. 2024 Jun 27;46:e-rbgo42.

4.)Association between COVID-19 vaccination and menstruation: a state of the science review. BMJ Sex Reprod Health. 2024 Jul 12;50(3):212-225. 

5.)Vesical Endometriosis in a male patient on treatment for papillary urothelial carcinoma. J West Afr Coll Surg. 2024 Jul-Sep;14(3):345-347.

6.)Lack of care pathway and poor symptom recognition are hindering care, report warns. BMJ. 2024 Jul 11;386:q1548. 

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Speaker 1
0:01

Welcome

to

Endobattery

Fast

Charged
,

a

series

dedicated

to

keeping

you

informed

and

empowered

in

the

realm

of

endometriosis
.

Teaming

up

with

board-certified

patient

advocates
,

we

bring

you

the

latest

articles
,

research

and

insights

to

equip

you

with

accurate

information

and

a

deeper

understanding
.

Whether

you're

expanding

your

knowledge
,

staying

updated

or

seeking

clarity
,

you're

in

the

right

place
.

I'm

your

host
,

alana
,

and

this

is

Endobattery

Fast

Charged

charging

and

empowering

your

life

with

knowledge
.

Welcome

back

to

Endobattery

Fast

Charged
,

where

we

dive

deep

into

the

electrifying

world

of

endometriosis

research
.

Prepare

to

be

left

wanting

more
,

because
,

let's

be

honest
,

who

doesn't

want

more

research

when

it

comes

to

endometriosis
?

Today
,

we're

plugging

into

the

latest

studies

to

supercharge

our

understanding

of

how

this

complex

condition

impacts

mental

health
,

medical

recognition

and

care
,

and
,

for

a

little

extra

voltage
,

we'll

even

explore

some

rare

and

intriguing

articles

that

might

just

blow

your

circuits
.

But

before

we

get

too

charged

up
,

remember

correlation

does

not

equal

causation
.

Just

because

two

things

are

linked

doesn't

mean

one

is

causing

the

other
.

Sort

of

like

how

having

a

cat

and

being

a

night

owl

might

be

connected
,

but

your

furry

friend

isn't

the

reason

you

stay

up

binge

watching

cat

videos
.

So

let's

dive

into

the

data
,

untangle

the

wires

of

correlation

and

causation

and

power

up

our

endo-knowledge

battery
.

Let's

get

started
.

All

right
,

let's

dive

into

this

fascinating

research

on

the

connection

between

our

mental

state

and

endometriosis

in

an

article

titled

the

Casual

Relationship

of

Depression
,

anxiety

and

Neuroticism

in

Endometriosis

a

Bidirectional
,

two-samsample

Mendelian

randomization

study
.

Imagine

your

genes

as

party

planners
.

Some

of

these

planners

are

responsible

for

throwing

the

kind

of

party

where

depression

and

neuroticism

are

the

star

guests
.

They

show

up

with

their

dark

clouds

and

anxious

vibes
,

making

the

party

a

bit

gloomy
.

Now

it

turns

out

that

if

these

two

gloomy

guests

are

on

the

invite

list
,

there's

a

higher

chance

that

endometriosis

will

crush

the

party

too
.

This

doesn't

mean

that

anxiety
,

who

is

often

part

in

the

moody

trio
,

gets

to

join

in

on

the

fun
.

No
,

anxiety

was

left

out

in

the

cold

on

this

one
.

No

party

crushing

for

them
.

Speaker 1
2:19

Researchers

took

a

closer

look

at

the

guest

list

by

using

a

genetic

approach
.

They

analyzed

data

from

studies

focusing

on

genes

associated

with

depression
,

anxiety

and

neuroticism
.

The

main

takeaway

those

with

a

genetic

predisposition

to

depression

and

neuroticism

have

a

higher

risk

of

developing

endometriosis
.

It's

like

the

genes

threw

a

surprise

party

and

endometriosis

decided

to

show

up

uninvited

when

depression

and

neuroticism

were

there
.

However
,

anxiety
,

despite

its

close

ties
,

didn't

seem

to

get

the

memo
.

But

before

we

jump

to

any

conclusions

and

blame

our

genes

for

everything
,

let's

remember

correlation

is

not

causation
.

Just

because

these

traits

often

show

up

together

doesn't

mean

one

causes

the

other
.

It's

more

like

they

have

an

overlapping

friend

circle
.

We

need

more

research

to

untangle

these

complex

webs
.

Meanwhile
,

addressing

endometriosis

with

a

biopsychosocial

approach

that's

a

fancy

term

for

looking

at

the

whole

person
,

including

their

mind
,

body

and

social

environment

can

help

manage

the

symptoms

spread

across

the

entire

system
,

both

physically

and

mentally
.

So

next

time

someone

mentions

endometriosis
,

depression

or

neuroticism
,

you

can

think

of

it

as

a

wild

interconnected

party

of

genes

where

some

guests

just

can't

help

but

show

up

together

and

remember
.

Anxiety

is

still

waiting

for

its

invite
.

Speaker 1
3:36

In

keeping

with

this

theme
,

a

recent

study

has

shed

some

light

on

a

topic

we've

touched

on

before
,

in

a

study

titled

Mental

Illness

and

Sleep

Disorders

Among

Women

with

Gynecological

Problems
.

Again
,

it's

like

a

detective

novel
,

minus

the

car

chases

and

plot

twists
.

Instead

of

a

magnifying

glass
,

researchers

used

medical

claims

data

spanning

four

years

from

adult

employees

of

a

big

corporation
.

The

results

the

patients

with

gynecological

issues
,

specifically

pain
,

endometriosis
,

pelvic

inflammation

and

bleeding

were

more

likely

to

experience

mental

illness

and

sleep

disorders
.

Imagine

Sherlock

Holmes

saying

elementary
,

my

dear

Watson
,

but

with

a

stethoscope

instead

of

a

pipe
.

The

study

found

that

individuals

with

gynecological

problems

were

50%

more

likely

to

have

mental

health

issues

and

44%

more

likely

to

suffer

from

sleep

disorder
.

That's

a

pretty

significant

clue

pointing

towards

the

interconnectedness

of

our

bodily

systems
.

The

researchers

are

basically

waving

a

big

red

flag

saying

hey
,

clinicians
,

we

need

to

take

a

look

at

the

whole

picture

here

Now

again
.

Don't

go

thinking

correlation

equals

causation
.

Speaker 1
4:42

This

isn't

some

conspiracy

theory

where

everything

is

magically

linked
,

but

it

is

a

fascinating

piece

of

the

puzzle

that's

catching

the

medical

community's

attention
.

Think

of

it

as

an

invitation

to

a

more

holistic

approach

to

treating

conditions

like

endometriosis
.

If

you're

dealing

with

chronic

pain

or

pelvic

inflammation
,

it

makes

sense

that

it

could

mess

with

your

mental

health

and

sleep
.

It's

like

trying

to

sleep

on

a

lumpy

mattress

while

dealing

with

a

noisy

neighbor

Not

exactly

conducive

to

rest

and

relaxation
,

right
?

In

conclusion
,

this

research

is

a

gentle

reminder

that

our

bodies

are

intricate
,

interconnected

systems
.

If

you're

dealing

with

gynecological

issues
,

don't

be

surprised

if

it

impacts

other

areas

of

your

health
.

And

for

the

medical

professionals

out

there
,

it's

a

call

to

action

to

consider

the

full

body

approach

when

treating

patients
.

So

let's

keep

an

eye

on

this

emerging

data

and

hope

that

it

leads

to

better

care

and

outcomes

for

everyone
.

If

nothing

else
,

it's

a

good

reason

to

treat

yourself

to

a

good

night's

sleep
.

You've

earned

it
.

Speaker 1
5:40

In

this

next

article

titled

the

Impact

of

Surgical

Treatment

for

Deep

Endometriosis

Metabolic

Profile
,

quality

of

Life

and

Psychological

Aspects
,

researchers

embarked

on

this

ambitious

study

involving

435

patients

with

deep

endometriosis
,

sourced

from

44

endometriosis

centers
.

Picture

a

global

gathering

of

people

suffering

from

the

same

stubborn

condition
,

all

in

their

mid-30s
,

ready

to

see

if

surgery

could

turn

things

around
.

Spoiler

alert

it

did
,

and

then

some
.

In

a

nutshell
,

the

study

explored

how

surgery

impacted

patients'

lives

across

the

seven

key

quality

of

life

areas
.

Imagine

you've

got

a

Swiss

Army

knife

of

well-being

post-surgery
.

Every

single

tool
,

pain

management
,

control

over

your

body
,

overall

well-being
,

social

support
,

self-image
,

work

life

and

sexual

relations

got

a

major

upgrade
.

It's

like

going

from

a

rusty

old

pocket

knife

to

a

shiny

new

multi-tool
.

But

wait
,

there's

more
.

Speaker 1
6:37

Researchers

didn't

stop

at

just

making

people

feel

better

mentally

and

socially
.

They

also

dove

into

the

nitty-gritty

of

metabolic

health
.

Post-surgery
,

the

average

level

of

various

metabolic

markers

took

a

nosedive

Total

cholesterol

dropped

from

8.2%
,

ldl

the

so-called

bad

cholesterol

by

12.8%
,

triglycerides

by

10.9%

and

fasting

blood

glucose

by

7.3%
.

Think

of

it

as

your

body's

internal

cleanup

crew
,

kicking

into

high

gear

after

surgery
,

leaving

your

metabolic

health

sparkling

clean
.

The

cherry

on

top
,

mental

health

saw

significant

improvements

too
.

Anxiety

and

depression

those

unwelcome

guests

decided

to

pack

their

bags

and

leave

after

surgery
.

It's

like

the

patient's

mind's

got

a

much-needed

vacation
,

far

away

from

the

constant

stress

and

worry
.

So

if

deep

endometriosis

were

a

party

crusher
,

wrecking

havoc

on

every

aspect

of

life
,

surgery

turned

out

to

be

the

bouncer

that

not

only

kicked

it

out

but

also

tidied

up

the

mess

it

left

behind
.

Speaker 1
7:39

Switching

gears

a

bit
,

let's

dive

into

the

fascinating

and

often

uncharted

waters

of

COVID-19

vaccines

and

menstrual

cycles
.

Since

the

pandemic

began
,

researchers

have

been

keen

to

understand

any

potential

links

between

COVID-19

vaccine

and

menstrual

health

changes
.

You

see
,

the

initial

clinical

trials

for

the

COVID

vaccine

didn't

specifically

study

menstrual

cycles
,

probably

because

period

tracking

doesn't

usually

make

it

into

the

list

of

high-stakes

medical

concerns
.

But

once

vaccines

rolled

out
,

the

anecdotal

reports

of

cycle

changes

after

vaccination

started

pouring

in

faster

than

you

could

say

PMS
.

Intrigued
,

and

perhaps

slightly

alarmed
,

researchers

conducted

a

comprehensive

state-of-the-science

review

titled

Association

Between

COVID-19

Vaccination

and

Menstruation
,

published

in

July

of

2024
.

Spoiler

alert

they

found

that

small

changes

in

menstrual

cycle

length
,

like

slightly

longer

cycles
,

did

indeed

occur

post-vaccination
.

It's

like

your

uterus

decided

it

needed

a

tiny

vacation
.

Alongside

this
,

some

women

reported

other

menstrual

characteristics

pain
,

heavier

flow

and

even

inner

menstrual

bleeding
.

Basically
,

for

some
,

getting

vaccinated

was

like

their

period

deciding

to

throw

a

little

party

of

its

own
.

Speaker 1
8:55

Now
,

for

those

living

with

endometriosis
,

the

story

took

a

more

serious

turn
.

Research

has

indicated

that

people

with

endometriosis

who

received

COVID-19

vaccines

experienced

more

severe

menstrual

cycle

issues
.

Think

more

fatigue
,

increased

pain

and

irregular

periods
,

because

having

endometriosis

isn't

enough

of

a

monthly

adventure

already
.

It's

like

the

COVID

vaccine

RSVP'd

to

your

endometriosis

party

and

brought

along

some

uninvited

guests
.

The

study

team

has

made

a

strong

case

for

incorporating

menstrual

health

as

key

outcomes

in

future

clinical

trials
.

Imagine

a

world

where

tracking

your

menstrual

cycle

gets

as

much

attention

in

clinical

research

as
,

say
,

your

cholesterol

levels
.

They

also

called

for

more

research

on

this

front
,

hopefully

leading

to

a

day

when

we

can

all

say

remember

when

no

one

cared

about

how

vaccines

affected

our

periods
.

Those

were

the

dark

ages
.

So

there

you

have

it
,

the

grand

scheme

of

pandemic

research
.

Menstrual

cycles

are

finally

getting

a

bit

of

a

spotlight
.

They

deserve

proving

once

again

that

science

is

nothing

if

not

full

of

surprises
.

Speaker 1
10:02

So

are

you

ready

for

this

next

article
,

which

is

a

bit

unexpected

I

am

In
?

The

article

titled

Visceral

Endometriosis

in

a

Male

Patient

on

Treatment

for

Papillary

Urethral

Sarcoma

was

fascinating
.

So

picture

this

a

60-year-old

guy

strolls

into

a

clinic

and
,

lo

and

behold
,

he's

got

bladder

endometriosis
.

Yes
,

you

heard

that
,

right
.

Hold
,

he's

got

bladder

endometriosis
.

Yes
,

you

heard

that

right
.

Speaker 1
10:24

Endometriosis
,

the

condition

most

commonly

found

in

women
,

has

somehow

taken

up

residence

in

a

man's

bladder
.

Now
,

that's

not

something

you

see

every

day
.

What's

really

turning

heads

in

the

medical

community

is

the

rarity

of

this

scenario
.

Sure
,

male

endometriosis

isn't

entirely

unheard

of
,

but

it's

usually

found

in

the

context

of

previous

estrogen

treatments

for

conditions

like

prostate

cancer
.

This

guy
,

though
,

clean

slate
,

no

history

of

estrogen

therapy
,

no

cancers

messing

around
,

just

straight

up

case

of

bladder

endometriosis

out

of

the

blue
.

Speaker 1
10:58

Researchers

are

scratching

their

heads

over

this

one
.

It's

like

finding

a

unicorn

in

your

backyard
.

It's

fascinating

and

a

bit

perplexing

all

at

once
.

This

case

study

published

recently

dives

deep

into

the

nitty

gritties

of

how

this

condition

manifested

in

such

an

unexpected

patient
.

They're

breaking

down

the

clinical

signs

and

histology

reports

Everything

you'd

expect

in

a

medical

mystery

thriller
.

Speaker 1
11:22

Now
,

while

we're

on

this

topic
.

Let's

talk

about

the

implications
.

Understanding

how

and

why

this

happened

could

potentially

shed

light

on

new

facets

of

endometriosis

that

we've

never

explored

before
.

It's

like

opening

a

door

to

a

whole

new

wing

of

medical

knowledge
,

one

where

gender

norms

and

disease

patterns

might

need

a

bit

of

a

rewrite
.

So

hats

off

to

the

researchers

who

cracked

this

case

wide

open
.

Speaker 1
11:45

It's

not

every

day

you

get

to

witness

such

a

unique

twist

in

a

medical

saga
.

Who

knows
,

maybe

next

time

we'll

find

endometriosis

hanging

out

somewhere

even

more

unexpected
.

Stay

curious
,

folks
.

The

world

of

medicine

never

fails

to

surprise

us
.

You

know
,

it's

no

secret

that

endometriosis

is

often

overlooked
,

but

now

we've

got

some

solid

research

to

back

it

up
.

Speaker 1
12:06

Picture

you've

got

this

chronic

condition

and

yet
,

unlike

other

long-term

illnesses
,

there's

no

clear

path

for

treatment

within

the

NHS
.

Shocking

right
?

Well
,

that's

exactly

what

a

recent

UK

report

titled
.

Lack

of

Care

Pathway

and

Poor

Symptom

Recognition

are

Hindering

Care
,

report

Warns

found
.

The

study

conducted

by

the

National

Confidential

Inquiry

into

Patient

Outcomes

and

Death

Reviewed

941

patients

and

the

results

were

pretty

disheartening
.

More

than

half

of

these

patients

had

to

make

multiple

trips

to

their

GP

before

getting

any

serious

investigation

or

treatment
.

The

lack

of

clear

care

pathway

and

poor

recognition

of

symptoms

are

leaving

many

patients

without

the

support

they

desperately

need
.

In

fact
,

the

review

of

case

notes

showed

a

significant

number

of

patients

were

not

receiving

appropriate

care
.

This

isn't

just

a

minor

oversight
.

It's

a

huge

gap

in

the

healthcare

system

that

needs

addressing
.

Speaker 1
13:04

The

research

team

didn't

just

point

out

the

problem
,

they

offered

solutions
.

They've

called

for

the

NHS

to

establish

a

formal

care

pathway

for

endometriosis
.

They're

also

pushing

for

increased

awareness

among

healthcare

professionals
,

emphasizing

that

endometriosis

is

a

chronic

disease

and

should

be

treated

with

the

same

seriousness

as

other

chronic

conditions
.

And

let's

not

forget
,

more

training

and

recognizing

the

symptoms

is

crucial
.

Just

think

about

it

Every

country

could

follow

this

lead
.

Imagine

a

world

where

endometriosis

is

taken

seriously
,

where

patients

aren't

left

in

limbo

and

where

healthcare

professionals

are

fully

equipped

to

provide

the

right

support
.

It's

a

big

ask
,

but

it's

definitely

a

step

in

the

right

direction
.

If

you

want

to

continue

learning

more

about

these

articles
,

make

sure

that

you

check

out

the

links

in

the

description

of

this

podcast

and

continue

feeling

your

knowledge

about

endometriosis

research
,

because

the

more

we

know
,

the

better

we

can

advocate
.

Until

next

time
,

continue

advocating

for

you

and

for

those

that

you

love
.

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