Beyond Excision: Why Your Nerves and Neuropelviology Hold the Truth About Your Pain, With Prof. Marc Possover

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Beyond Excision: Why Your Nerves and Neuropelviology Hold the Truth About Your Pain, With Prof. Marc Possover
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Professor Marc Possover reveals how our nervous system drives endometriosis pain and offers practical tools for managing symptoms through vagus nerve regulation. This groundbreaking conversation challenges traditional views of endometriosis by exploring neuropelviology – the study of pelvic nerves – and how nerve function impacts everything from pain perception to fertility.

• The pelvic nervous system controls all pelvic functions and pain signals
• Our autonomic nervous system has two branches: sympathetic (fight-or-flight) and parasympathetic (rest-and-digest)
• Endometriosis activates the sympathetic nervous system, creating widespread effects beyond the pelvis
• Vagus nerve stimulation can increase parasympathetic activity and decrease pain
• Simple techniques like ear stimulation, breath work, positive thinking, and physical activity can regulate the nervous system
• Symptoms often dismissed as “comorbidities” are actually part of one connected nervous system dysfunction
• Many patients with persistent pain after surgery may be experiencing nervous system sensitization rather than disease recurrence
• Future treatments may include neuromodulation techniques that decrease both pain and inflammation
• Understanding neuropelviology could reduce unnecessary surgeries and improve outcomes
• Both patients and doctors need education about the nervous system’s role in endometriosis

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Introduction to Neuropelviology

Speaker 1
0:00

What

if

I

told

you

that

your

nervous

system

has

more

to

do

with

your

endometriosis

pain

than

you

probably

think
?

And

what

if

I

told

you

there's

practical

tools

in

place

that

can

help

you

with

your

pain

management
?

Have

you

ever

heard

of

neuropelviology
?

Maybe

you've

even

heard

about

fight

or

flight
,

or

rest

and

digest

and

the

vagus

nerve
.

Professor

Mark

Possover

is

joining

me

today

to

go

over

that

and

so

much

more
.

So

stick

around
.

Speaker 1
0:27

Welcome

to

EndoBattery
,

where

I

share

my

journey

with

endometriosis

and

chronic

illness
,

while

learning

and

growing

along

the

way
.

This

podcast

is

not

a

substitute

for

medical

advice
,

but

a

supportive

space

to

provide

community

and

valuable

information

so

you

never

have

to

face

this

journey

alone
.

We

embrace

a

range

of

perspectives

that

may

not

always

align

with

our

own
,

believing

that

open

dialogue

helps

us

grow

and

gain

new

tools
.

Join

me

as

I

share

stories

of

strength
,

resilience

and

hope
,

from

personal

experiences

to

expert

insights
.

I'm

your

host
,

alana
,

and

this

is

EndoBattery

charging

our

lives

when

endometriosis

drains

us
.

Welcome

back

to

Endobattery
.

Grab

your

cup

of

coffee

or

your

cup

of

tea

and

join

me

at

the

table
.

Speaker 1
1:12

Today's

guest

has

built

his

career

on

a

bold

but

vital

belief

that

suffering

pain

should

not

be

a

life

sentence
,

and

for

Professor

Mark

Possover
,

that

belief

isn't

just

a

philosophy
,

it's

a

mission
.

As

a

world-renowned

pioneer

in

neuropelviology

yes
,

you

heard

that

right

he

has

transformed

how

we

understand

and

treat

chronic

pelvic

pain
,

especially

when

the

source

is

elusive

or

deemed

untreatable
.

His

work

bridges

the

worlds

of

gynecology
,

neurology

and

minimally

invasive

surgery

to

target

the

pelvic

nerve

directly
,

often

bringing

relief

to

patients

who've

been

told

to

simply

live

with

it
.

Professor

Possover

isn't

just

treating

symptoms
.

He's

finding

the

root

cause
,

especially

in

cases

involving

nerve

entrapment
,

endometriosis

and

neuropathic

pelvic

pain
.

His

methods

have

given

hope

to

countless

people

who

have

felt

like

they've

run

out

of

options
.

Speaker 1
2:02

So

if

you've

ever

wondered

what's

really

going

on

when

no

one

seems

to

have

answers
,

this

episode

is

for

you
.

Please

help

me

in

welcoming

Professor

Mark

Possover

to

the

table
.

Thank

you
,

professor

Possover
,

for

sitting

down

with

me

today
,

and

this

is

a

complete

honor

for

me

to

be

able

to

sit

in

this

space

with

you

and

learn

from

you
,

because

you

are

a

genius

when

it

comes

to

nerves
.

So

thank

you

for

taking

the

time

to

sit

down

with

me

and

expel

your

knowledge

to

us
.

Speaker 2
2:34

Thank

you

very

much

for

the

invitation
.

The

pleasure

and

the

honor

is

for

me

definitely
.

I

think

it's

not

a

question

to

be

a

genius
,

but

I

spent

simply

20

to

25

years

of

my

life

to

try

to

understand

the

pelvic

sympathetic

and

parasympathetic
,

the

pelvic

nervous

system
,

which

is

not

easy
.

Speaker 1
2:52

Yeah
,

it's

not

easy
,

but
,

man
,

it

is

so

central

to

what

we

do
.

Can

you

explain

what

you

do
?

Who

you

are

and

why

this

conversation

is

going

to

be

so

important

is

because

of

what

you've

done

in

your

career
,

but

also

this

is

your

passion
.

Can

you

explain

a

little

bit

about

this
?

Speaker 2
3:14

So
,

as

you

said
,

I'm

Marc

Possevert
.

Marc

is

my

surname
.

I'm

a

French

guy
.

I'm

working

in

Switzerland
,

but

I'm

a

French

guy
.

Speaker 2
3:21

I

started

my

medical

study

with

15

and

with

22
,

I

was

a

cardiovascular

surgeon
.

So

I

have

a

little

bit

of

a

different

vision

of

the

pelvis

than

gynecologists
.

And

you

know
,

when

I

started

my

career

in

cardiovascular

surgeon

surgery

it

was

in

France
.

That

time
,

when

the

gynecologist

made

a

mistake

in

terms

of

bleeding
,

they

always

call

the

cardiovascular

surgeon
.

And

because

I

was

a

young

guy

in

the

team

in

the

department

of

cardiovascular

surgery
,

so

my

chef
,

my

boss
,

always

said

you

have

to

go

to

the

gynecologist
,

try

to

solve

the

situation
.

So

I

learned

how

to

manage

complication

in

the

pelvis

before

I

was

able

to

perform

even

a

sterilization
.

And

then
,

because

cardiovascular

surgery

was

every

day

more

or

less

the

same
,

I

was

looking

a

little

bit

on

the

left
,

on

the

right

and

I

found

the

gynecology
,

or

the

gynecology

obstetric
.

And

I

found
,

yeah
,

it's

fascinating

the

gynecology
,

because

it's

not

like

cardiovascular

surgery
,

you

have

just

to

deal

with

health

or

with

vascular
.

But

in

gynecology

you

have

just

to

deal

with

health

or

with

vascular
,

but

in

gynecology

you

have

to

deal

with

women
,

you

have

to

deal

with

life
.

You

have

to

deal

with

obstetric

microsurgery
,

laparoscopic

surgery
,

oncology
,

everything
.

Speaker 2
4:35

And

then

I

started

my

fellowship

in

gynecology

by

moving

to

Germany

and

from

there

I

become

a

specialist

in

oncology

and

endometriosis

because

at

that

time
,

for

more

or

less

30

years
,

oncology

and

endometriosis

were

one

speciality

and

more

or

less

in

Germany

at

that

time

we

were

what

we

call

in

the

United

States

pelvic

surgeon
.

So

I'm

doing

all

kinds

of

pelvic

surgery
,

bladder

surgery
,

bowel

surgery

and

over

the

year
.

What

I

was

missing

is

when

we

were

doing

a

lot

of

surgery
,

big

surgeries

in

the

pelvis
,

we

would

induce

what

we

call

a

high

morbidity
.

Morbidities

that

mean

complication
,

and

I'm

not

talking

from

complication

during

the

surgery

like

damage

of

the
,

the

bladder

of

the

blood

vessel
,

but

the

problem

at

that

time

30-40%

of

our

patients

were

not

able

to

empty

the

bladder

after

the

surgery
,

whether

we

were

performing

surgery

for

cancer

or

for

endometriosis
.

And

you

know
,

in

cancer

patients

at

that

time
,

when

you

say

to

a

patient
,

okay
,

that

is

a

price

to

be

alive
,

more

or

less

a

patient

accepts

the

situation
.

Speaker 2
5:47

But

when

you

have

to

deal

with

a

young

woman

25
,

30

years

old
,

she

wants

to

get

pregnant
,

she's

just

married

to

you
,

do

a

surgery

and

then

she

has

to

use

a

catheter
.

That

is

a

shame

and

that's

the

reason

why

I

was

starting

to

think

we

have

to

reduce

this

morbidity

by

preserving

the

organs

in

the

pelvis

which

are

in

charge

of

all

these

different

functions

and

these

organs

on

the

pelvic

nerves
.

And

that's

the

reason

why

I

started

to

focus

my

attention

on

the

pelvic

nerves
.

And

for

20
,

30

years

we

introduced

laparoscopy

in

the

gynecology

and

laparoscopy

is

like

a

microscope

so

you

can

see

the

small

nerve

from

less

than

2.1

mm

very

big

of

the

screen
.

And

that

was

the

start

of

the

neuropelviology

what

I

became

over

the

years
.

I'm

still

doing

endometriosis

and

oncology
,

but

more

than

90%

of

my

work

now

is

neuropelvology
,

so

I'm

a

kind

of

neurologist

for

the

diagnosis

and

neurosurgeon

in

the

pelvis
.

Speaker 1
6:56

Which

is

fascinating

because

I

think

a

lot

of

times
,

a

lot

of

us

think

about

endometriosis

as

just

the

disease
.

We

don't

think

about

it

as

it

being

a

nervous

system

issue
.

Can

you

walk

us

through

why

the

nervous

system

plays

such

a

huge

part

in

endometriosis

and

why

this

matters

not

only

to

the

patient

but

to

the

provider
?

Speaker 2
7:19

Yeah
,

the

problem

endometriosis
.

You

know

it's

not
,

it's

just

a

cause
,

the

cause
.

As

when

you

feel

pain

during

your

menstruation
,

it's

not

because

you

have

endometriosis
,

you

know

it's

not
,

it's

just

a

cause
,

the

cause
.

As

when

you

feel

pain

during

human's

bleeding
,

it's

not

because

you

have

endometriosis

in

your

brain
.

You

feel

pain

because

within

the

pelvis
,

everywhere
,

but

not

just

in

the

pelvis
.

There

is

no

place

in

your

body

where

there

are

no

nerves
,

and

the

nerves

have

always

two

functions
.

Speaker 2
7:42

One

function

is

to

bring

information

to

the

brain
,

and

one

of

these

information

is

pain
.

But

it's

also

information

like

my

bladder

is

full
,

I

have

to

go

on

the

toilet

or

I

have

sexual

activity

or

I

have

some

desire
,

and

so

now

I'm

bringing

information

to

the

brain
,

down
,

like

I

want

to

empty

my

bladder

or

nerve

and

bring

even

a

formation

to

the

pelvic

organ
.

Now

is

time

to

get

an

ovulation

or

now

is

time

to

get

a

bleeding
.

So

an

endometriosis

is

just

one

of

the

cause

that

can

induce

damage

or

irritation

of

the

nerves
,

but

are

not

the

only

one
.

If

you

have

another

infection
,

if

you

have

a

myoma

compressing

the

nerve

or

pathology

of

the

same

nerve

themselves
,

the

patient

will

feel

pain
.

So

in

endometriosis
,

patients

have

infertility
,

dysmenorrhea
,

pain

during

intercourse
,

pain

during

main

bleeding

because

the

nerves

are

involved
.

Without

nerves
,

we

would

not

have

either

pain

or

ovulation

or

bleeding
,

because

the

nerves

control

everything
.

Speaker 1
8:53

Right
,

and

there's

one

nerve

in

particular

that

is

the

driver

of

this

and

that's

the

vagus

nerve
.

Can

you

explain

the

role

that

this

nerve

plays

in

our

body
,

in

our

nervous

system
?

The

role

that

this

nerve

plays

in

our

body
,

in

our

nervous

system
?

Because

I

think

something

that

you

brought

to

light

was

the

fact

that

it

is

kind

of

a

driver

in

most

all

pain
,

not

just

endometriosis
.

It

drives

pain
,

whether

we're

scratching

our

leg

on

a

bush

or

it's
.

You

know

we're

walking

and

we're

having

a

hard

time

walking

or

whatever

that

case

is
.

Can

you

explain

that

a

little

bit

better

for

us

and

why

this

matters

so

much
?

Speaker 2
9:28

Maybe

I

have

to

explain

a

little

bit

the

nervous

system
,

not

just

in

the

pelvis
.

You

have

two

kinds

of

nerves
.

You

have

what

we

call

somatetic

nerve
,

that

is

the

nerve

which

command

the

red

muscle
.

So

if

you

want

to

move

a

leg

is

because

you

have

an

activation
,

for

example
,

of

the

somatic

nerve
.

And

behind

this

somatic

nerve

you

have

a

note
,

another

nervous

system
,

what

we

call

autonomic

nervous

system
,

of

vegetative

nervous

system
.

That

is

a

nerve

system

we

cannot

control
.

Speaker 2
10:03

For
,

for

example
,

if

I'm

breathing

and

there's

no

need

for

me

to

think

about

that

or

if

my

cardiac

is

working
,

it's

because

I

have

an

autonomic

nerve

system
.

Or
,

for

example
,

in

the

pelvic

cavity
,

the

bladder
.

If

I

want

to

go

on

the

toilet

and

to

empty

my

bladder
,

my

brain

is

giving

the

information
,

do

it
.

But

then

the

autonomic

nerve

system

is

doing
.

It's

no

need

for

me

to

think
.

I

am

already

avoiding

my

bladder
.

That's

the

reason

why
,

suppose

you

want

to

empty

your

bladder
,

you

go

on

the

toilet

and

suppose

you

have

a

book
,

so

you

can

say

okay
,

I

want

to

pee
.

The

brain

will

give

you

information
,

but

the

vegetative

nerve

system

will

do

by

itself
.

So

there's

no

need

for

you

to

think

while

you're

empty

your

bladder
,

you

can

read

a

book
,

because

the

autonomic

nerve

system

does

that

by

its

own
.

Speaker 2
10:59

And

the

vegetative

nerve

system

is

the

nerve

system

that

the

Chinese

medicine

well

know
.

And

you

have

two

systems
.

You

have

a

bad

nerve

system

and

a

good

nerve

system
.

And

the

bad

nerve

system

is

what

we

call

the

sympathetic
.

Meet Professor Mark Possover

Speaker 2
11:15

It's

called

sympathetic

in

French
,

sympathetic

would

mean

nice
,

but

it's

not

a

nice

nerve

system
.

Speaker 2
11:22

The

sympathetic

nerve

system

is

involved

in

its

increase

in

pain
,

in

dysmenorrhea
,

if

you

have

headache
,

if

you

are

worried
,

if

you

don't

feel

good
.

That

is

the

sympathetic

nerve

system
.

And

on

the

other

side

you

have

the

parasympathetic

nerve

system
,

which

is

called

the

rest

and

digest

nerve

system
.

And

this

parasympathetic

nerve

system
,

which

is

called

the

rest

and

digest

nerve

system
,

and

this

parasympathetic

nerve

system

is

for

the

well-feeling
.

So

if

you

have

no

pain
,

if

you

feel

good

in

your

life
,

you

enjoy

your

life
,

you

can

properly

void

your

bladder
,

you

are

properly

intercourse
.

And

all

this

thing

is

because

you

have

the

autonomic

nerve

system
,

course
,

and

all

this

thing

is

because

you

have

the

autonomic

nerve

system
.

And

these

both

nerve

system

system

are

in

balance
.

So

the

parasympathetic
,

the

good

autonomic

nerve

system

is
,

if

it

increase
,

it

will

decrease

the

sympathetic

nerve

system
.

Speaker 2
12:19

So

suppose

you

have

pain
.

Pain

means

you

have

an

activation

of

the

sympathetic

nervous

system
.

You

can

say

I

will

reduce

this

sympathetic

nervous

system
,

for

that

I

will

take

painkillers
.

There

is

another

way

to

say
,

because

they

are

in

balance
.

You

can

reduce

the

sympathetic

nervous

system

and

that

way

the

wellness

system

will

increase
.

Or

you

will

say

it

will

increase

by

myself
,

without

painkiller
.

The

parasympathetic

nerve

system

and

the

parasympathetic

nerve

system
,

you

have

two

systems

one

in

the

pelvis
,

which

you

cannot

control

with

the

brain
,

and

you

have

the

second

system

is

the

vagus

nerve
.

And

the

vagus

nerve

is

a

nerve

that

emerges

directly

from

the

brain
.

It's

running

in

the

neck
,

outside

the

spinal

cord
,

and

goes

in

your

abdomen

and

will

control

your

cardiac

activity
,

the

lung
,

all

the

different

functions
.

So

if

you

are

able

to

activate

the

vagus

nerve

in

your

life
,

you

will

be

more

happy
.

It's

as

simple

as

that
.

Speaker 1
13:32

But

is

that

an

easy

thing

to

do
,

which

is
,

I

think
,

for

a

lot

of

us
?

We're

like

how

do

we

do

that
?

How

do

we

activate

that

vagus

nerve
?

Speaker 2
13:43

I

think

you

have

three

possibilities
.

One

is

to

activate

the

vagus

nerve

passively
,

and

one

very
,

very

easy

way

is

what

we

call

the

transauricular

vagus

nerve

stimulation
,

because

the

vagus

nerve

will

send

branch

everywhere
,

some

nerve

fibers

everywhere

in

the

body
,

and

some

of

these

fibers

reach

the

ear
.

And

these

fibers

are

very

important

because

they

are

directly

connected

to

the

brain
,

so

they

are

tense

device
.

Tense

device

that

means

that

bring

very

nice

electricity
.

There

is

some

device

you

bring

here

on

the
,

what

we

call

the

conch
,

and

then

you

can

activate

the

vagus

nerve
.

For

example
,

my

patient

affected

by

endometriosis

or

spinal

cord

injury

patient

who

are

depressive
,

I

advise

them

please
,

in

the

morning
,

in

the

evening
,

10

minutes

when

you

are

lying

down

in

your

bed
,

try

to

do

a

little

bit

stimulation

of

the

vagus

nerve

here
.

And

there

is

another

way
.

It's

how

you

are
.

Speaker 2
14:46

If

you're

staying

up

in

the

morning

and

you

say
,

oh
,

today

is

a

bad

day
,

you

have

high

risk

that

it

will

be

a

bad

day
.

If

you're

coming

up
,

staying

up

and

you're

obliged

to

think
,

oh
,

today

is

a

beautiful

day
,

I

will

have

a

blue

sky
.

If

you

try

to

convince

yourself

that

it

will

be

a

beautiful

day
,

you

have

much

better

chance

to

get

a

beautiful

day
.

And

there

is

another

source

method

to

increase

the

vagus

nerve
.

It's

what

we

call

the

subliminals
.

Subliminals

are

audios
,

they

are

music
,

where
,

in

subliminals
,

you

can

bring

a

message

in

a

high

frequency
,

so

you

will

not

hear

the

message
,

but

your

brain

will

hear

it
.

And

in

this

music
,

which

is

very

peaceful
,

you

can

bring

the

message
.

Today

it

will

be

a

nice

day
,

you

will

be

happy
,

you

will

have

no

pain

Okay
,

you

will

get

your

man

bleeding
,

but

you

will

see

it

will

be

much

better

than

the

last

month
.

And

when

you

do

that
,

it's

like

a

kind

of

auto-suggestion

which

will

increase

the

activity

of

the

parasympathetic

nerve

and

your

day

will

be

better

Interesting
?

Speaker 1
16:00

Is

this

impactful

with

like

breath

work

and

doing

body

movement
,

if

you

can
,

and

things

like

that
,

because

we

hear

a

lot

about

that
.

How

important

is

that

to

increasing

that

parasympathetic

system
?

Speaker 2
16:15

Yes
,

with

sport

activity
,

and

for

that

I'm

pretty

nice
,

located

here
.

I'm

in

Switzerland

because

we

have

the

mountain
,

and

the

mountain

is

really

swimming

and

hiking
,

on

both

methods

Not

to

increase

the

vagus

nerve
,

of

course
,

if

you're

in

the

mountain

and

you

see

a

sea
,

it's

beautiful
,

it

will

make

you

happy
.

Then

you

have

an

activation

of

the

parasympathetic

nerve
.

But

if

you're

swimming

or

if

you're

hiking
,

you're

embracing

and

when

you're

embracing

a

lot

you

will

induce

a

massage

of

what

we

call

the

plexus

solar

and

this

way

you

will

decrease

the

activity

of

the

sympathetic

nerve

system

and

that

way

will

increase

the

parasympathetic

nerve

system
.

So

it's

true
,

if

you

are

doing

sport

activity

running
,

hiking
,

swimming

you

will

feel

the

pain

much

less
.

And

if

you're

thinking

about

a

patient

or

a

woman

who

are

doing

very

lot

of

activity
,

sport

activity

and

usually

much
,

much

less

pain

during

men's

bleeding

than

a

patient

who

are

sitting

home

and

yeah
,

it's

simple

like

that

it's

anatomically

activity

will

decrease

the

sympathetic

nerve

system
.

And
,

by

the

way
,

smoking

will

increase

the

activity

of

the

sympathetic

nerve

system
.

Speaker 1
17:37

Interesting
.

What

else

increases

the

sympathetic

system
?

Stress

probably
,

I

would

assume
.

Speaker 2
17:44

Exactly

In

principle
.

You

have

just

the

sympathetic

nerve

system

is

a

fight

and

flight

nerve

system
,

so

you

have

just

to

sing

when

you're

afraid
.

So

let's

give

an

example
.

Three

at

night

we

met

together

on

the

street
.

It's

dark

and

I

want

to

kill

you
.

You

will

not

start

to

smile
.

Speaker 2
18:05

So

if

you

are

afraid

for

me
,

you

have

only

one

thing

in

mind

go

away
.

You

will

try

to

run
.

Run

means

you

will

need

blood

for

the

muscle
,

blood

for

the

heart
,

blood

for

your

brain
,

blood

from

the

lung
.

So

the

blood

in

the

rest

of

the

body

will

be

decreased
.

And

that's

the

reason

why
,

for

example
,

when

you

are

affected

by

endometriosis

and

you

have

another

activity

of

the

sympathetic

nervous

system
,

you

are

white

in

face
.

That's

the

reason

why

your

fingers

are

cold
.

Your

body

is

cold
,

but

when

you're

afraid

you

will

start

sweating
.

So

when

you

have

a

patient

with

another

activity

of

the

sympathetic

system

because

I

want

to

kill

you

in

the

night
,

or

because

you

have

endometriosis
,

you

will

be

tired
,

you

will

be

white

in

face
,

you

will

be

cold
,

you

will

look

for

something

warm
,

but

if

I

give

you

the

hand
,

I

will

feel

that

your

hand

is

cold

but

wet
.

Speaker 2
19:10

Now
,

listening

about

the

night

when

I

try
,

when

you

have

to

write

in

the

night
,

it's

like

the

cats
.

You

have

to

open

the

black

in

your

eyes

to

see

more

light
.

That

means

when

you

have

another

activity

of

the

sympathetic

nervous

system
,

the

black

in

your

eyes

will

get

open
.

It's

what

we

call

a

midriasis
.

And

then

simply

think

about

people

in

the

television
.

When

they

have

to

go

in

the

television
,

usually

they

have

a

glass

of

water
.

Speaker 2
19:41

Why
?

Because

when

you

have

another

activity

of

the

sympathetic

nervous

system
,

the

salivation

in

your

mouth

will

decrease

and

that

way

your

lips

will

get

dry
.

You

will

start

being

nervous
,

your

cardiac

activity

will

increase
,

you

will

start

to

breathe

much

frequently
,

and

all

these

signs

you

can

see

when

a

patient

is

coming

in

your

office
.

You

see

she's

white

in

face
,

the

black

is

dilated
,

she

has

a

middle

rashes
,

the

lips

are

dry
,

the

hand

is

cold

but

wet
.

You

see

under

the

shoulder

she's

sweating

but

she

has

cold
.

If

you

see

she's

quite

nervous
,

look

here
.

When

you

see

increased

cardiac

activity

and

you

have

the

feeling

she

has

to

breathe

a

lot
,

you

know

she

has

an

overactivity

of

the

sympathetic

nerve

system
.

And

in

the

life

of

the

woman
,

the

cause

number

one
,

which

every

month

will

increase
,

activate

the

sympathetic

nervous

system

is

endometriosis
.

Speaker 1
20:50

And

what's

interesting

about

this

is

that

it

sounds

so

simple

and

yet

so

complex
,

because

it's

the

human

side

of

us

mixed

with

the

body

side

of

us
,

like

the

emotion

plus

the

body
,

so

combining

those

two

seems

impossible

to

manage

or

impossible

to

like

Understanding the Pelvic Nervous System

Speaker 1
21:10

think

past

sometimes

for

a

lot

of

us
.

Why

is

it

important

that

we

address

this

and

acknowledge

that

though
?

Because

I'm

sure

you

see

some

of

the

patients

who

have

severe

endometriosis
,

because

you

do

a

lot

of

nervous

system

stuff

for

endometriosis

and

sciatic

endometriosis

and

teach

neuropelviology
,

so

you're

seeing

a

lot

of

these

patients

who

are

very

in

their

sympathetic

system
.

How

do

we

regulate

this

as

patients
?

How

do
?

Why

is

this

important

to

understand

and

try

to

manage
?

Speaker 2
21:46

you

know

that

maybe

I

would

say

maybe

we

can
.

I

can

give

you

later

the

answer

how

it

is

important

for

a

patient
.

But

I

would

like

to

say

first

how

it's

important

for

doctors
.

Because

when

we

are

a

doctor

we're

sitting

in

front

of

a

patient
.

We

see

she's

quite

nervous
,

she

has

a

high

level

of

stress
,

she's

pale

in

face

and

she

explains

oh
,

I

have

pain

during

my

mind
,

bleeding

Everywhere

in

my

body
.

I

have

shoulder

pain

on

the

right
,

on

the

right

we

know

it

could

be

endometriosis

on

the

sciatic

nerve
.

No
,

no
,

no
,

doctor
,

I

have

pain

on

the

left
,

endometriosis

on

the

left
,

not

very

frequent
.

Speaker 2
22:25

Probably

the

patient

has

some

psychological

issue

and

you

open

the

door

and

the

patient

starts

and

you

know
,

during

my

menstruation

something

is

wrong
.

My

feet

are

getting

cold

and

I

get

pain

in

my

fingers
.

That

is

a

point

as

a

doctor

where

you

will

say
,

ok
,

ok
,

I

am

a

surgeon
,

an

endometrial

specialist
.

I

know

that

I

can

find

endometriosis

in

the

pelvis
,

but

not

in

the

shoes
,

not

in

the

fingers
,

not

in

the

left

shoulder
.

Probably

I

have

to

send

this

patient

first

to

a

psychologist
.

You

know
,

in

Europe

we

have

some

certification

center

in

endometriosis

and

it's

very

important

because

in

this

certification

you

have

always

to

give

the

name

of

a

psychologist
,

and

that

is

exactly

the

point
.

As

a

doctor
,

sometimes

probably
,

we

are

pushing

the

patient

much

too

fast

in

the

corner

of

the

psychology

and

once

you

understand

the

sympathetic

and

parasympathetic

nerve

system
,

then

you

will

understand

that

all

these

complaints

of

the

patient

are

part

of

the

same

disease
,

and

the

disease

is

the

irritation

of

the

pelvic

sympathetic

nerve
.

And

endometriosis

may

be

one

of

the

causes
,

but

it's

not

the

only

one
.

And

that

is

a

little

bit

my

fight
.

I

actually
,

over

the

last

30

years
,

I

was

fighting

for

awareness
,

increased

awareness
,

of

endometriosis
,

not

just

in

patients

but

also

in

doctors
,

and

now

I

have

the

feeling

we

are

going

a

little

bit

too

far
.

Speaker 2
24:02

When

patients

have

pain
,

it's

endometriosis
,

that's

it
.

And

that

is

too

easy
.

When

patients

have

an

issue

with

the

blood

or

issue

with

the

rectum
,

they

can

experience

exactly

the

same

pain

and

to

say
,

okay
,

let's

do

a

laparoscopy

and

remove

some

endometriosis
,

maybe

you

will

find

endometriosis
,

but

it's

not

the

proof

that

the

endometriosis

is

the

main

cause

of

the

pain
.

Right

and

now

for

the

patient
.

I

think

it's

very

important

to

be

aware

of

this

sympathetic

nerve

system
,

to

know
,

as

a

patient
,

I'm

not

crazy
.

It's

part

of

my

disease
.

It's

part

of

my

pathology
.

Once

again
,

if

I

have

pain

in

my

left

hand

during

my

men's

bleeding
,

it's

not

because

I

have

endometriosis

in

my

left

hand
,

but

because

I

have

an

overactivity

of

the

nervous

system
.

And

that

is

exactly

what

I

mentioned
.

How

many

patients

affected

by

endometriosis

have

pain

and

headache

during

men's

bleeding
?

Speaker 1
25:02

Yes
.

Speaker 2
25:03

You

have

not

to

look

for

an

endometriosis

in

the

brain
.

It

exists
,

but

it's

so

certain

I

never

saw

that

in

my

life
.

But

if

you

have

an

overactivity

of

the

sympathetic

nerve

system

because

of

an

endometriosis
,

for

example

in

the

pelvis
,

in

the

ovarian
,

that

will

induce

headache

because

of

an

overactivity

of

the

sympathetic

nerve

system

and

that's

a

treatment

is

not

to

give

you

antidepressant

of

some

painkiller

for

your

headache

but

to

treat

the

cause

of

the

overactivity

of

the

sympathetic

nerve

system

and

to

remove

the

endometriosis
.

Or

maybe

another

cause

and

one

of

the

main
,

second

main

cause

in

women

to

have

an

overactivity

of

the

sympathetic

nerve

system

is

what

we

call

outlet

obstipation

syndrome
.

Speaker 2
25:54

The

bowel

is

much

too

long
.

And

you

know

there

is

a

simple

trick
.

I

always

look

at

the

fingers

of

my

patient
.

When

a

patient

has

very

long
,

thin

fingers
,

you

can

be

sure

that

the

bowel

is

very

long
,

very

thin

and

is

making

kinking

inside

the

pelvis

and

then

the

patient

has

a

bloating

bowel

with

bloating

abdomen
,

pain

in

the

back
.

Sometimes

this

pain

even

goes

down
,

radiated

in

the

leg
,

not

in

the

back

of

the

sciatic

nerve

but

in

the

front

or

in

the

inside

of

the

thigh
,

and

that

is

what

we

call

outlet

obstipation

syndrome

and

it

will

induce

the

same

pain

like

in

endometriosis
,

but

not

just

during

men's

bleeding
,

but

in

some

patients

every

day
,

depending

from

food
,

what

they

are

eating
.

So

that

is

exactly

my

message
.

Endometriosis

is

only

one

cause
,

there

are

other

causes
.

Speaker 1
26:50

One

of

the

things

that

you

and

I

had

talked

about

previously

was

the

fact

that

it's

not

comorbidities
,

they're

all

one

thing
.

It's

all

one

thing
,

and

I

think

it's

hard

because

we

compartmentalize
.

We

got

to

solve

the

endometriosis

first
,

then

we

got

to

solve

this

issue
,

and

then

we've

got

to

solve

that

issue
.

It's

an

overwhelming

thing
,

and

we're

seeing

that

there's

a

lot

of

correlation

between

endometriosis

and

some

of

these

other

conditions
.

Speaker 2
27:17

Exactly
.

Speaker 1
27:18

Why

do

you

think

that

that

is

one

condition
,

and

can

you

explain

that

just

a

little

bit

for

us
?

Speaker 2
27:24

The

problem

is

the

way

we

are

thinking

in

medicine
,

because

we

are

thinking

in

a

small

area
.

So

when

I'm

a

gynecologist
,

I'm

dealing

with

the

uterus
,

the

tubes
,

the

vaginas
,

that's

it
.

So

when

a

patient

is

coming

and

said

well
,

mr

Possova
,

I

pain

every

month

during

my

brain
,

bleeding
.

Okay
,

could

be

endometriosis
.

Yeah
,

mr

Possova
,

I

have

another

problem
.

I

have

to

go

20

times

per

day

on

the

toilet

to

pee
.

Oh
,

that

is

an

issue

with

the

bladder
.

That

is

a

urologist
.

And

the

urologist

will

look

for

a

cause
,

like

I'm

looking

for

a

cause

for

pathology

of

the

genital

organ
,

like

endometriosis
.

He

will

directly

look

for

a

cause

that

may

affect

the

bladder
,

so

an

infection
,

interstitial

cytitis

or

something

like

that
.

And

if

the

patient

said

and

I

have

a

thirst

issue
,

I

have

irritable

bowel
,

then

you

send

the

patient

to

a

gastroenterologist

and

we'll

say

let's

do

a

colonoscopy
.

Your

mucosa

is

a

little

bit

red
,

you

have

some

chronical

inflammation

of

the

bowel
.

And

then

we

say
,

oh
,

this

patient

is

affected

from

endometriosis

and

with

comorbidity

bladder

rectum
.

The

patient

go

to

the

urologist
.

The

urologist

will

say

she's

affected

from

a

bladder

issue
,

with

comorbidity
,

endometriosis

and

irritability

bowel
.

And

I

say
,

no
,

the

pelvic

autonomic

nerve

system

is

the

same

for

the

bladder
,

for

the

rectum

and

from

the

genital

organ
.

So

it's

not

a

comorbidity
,

it's

one

pathology
,

the

irritation

of

the

sympathetic

nerve

system
.

And

that's

the

reason
.

Speaker 2
29:02

More

or

less

all

patients

affected

by

endometriosis
,

whether

it's

a

deep

endometriosis
,

an

adenomyosis
,

or

pelvic

endometriosis
,

peritoneum

endometriosis
,

they

will

all

experience

that

during

men's

bleeding

they

have

pain
,

they

have

to

go

more

frequently

on

the

toilet

to

pee
.

It's

easy

to

say

you

have

the

next

blood

infection
,

I

will

give

you

some

antibiotic
.

And

at

the

same

time

they

will

say

oh
,

during

my

men's

bleeding

I

have

diarrhea
.

Oh
,

let's

do

a

coloscopy
.

Maybe

you

have

endometriosis

of

the

rectum
,

maybe
.

Speaker 2
29:33

But

maybe

it's

an

irritation

of

the

pelvic

nerve
,

which

are

in

charge

of

all

these

organs

and

then

the

autonomic

nerve

system
.

We

have

not

to

consider

it

as

you

have

a

pelvic
,

an

abdominal
,

a

brain
,

a

spinal

cord
,

autonomic

nerve

system
.

It's

one

autonomic

nerve

system
.

So

if

you

have

an

irritation

in

the

autonomic

nerve

system

in

the

pelvis
,

you

will

have

an

activation

of

the

autonomic

nerve

system

in

the

pelvis
.

You

will

have

an

activation

of

the

autonomic

nervous

system

in

the

whole

body

and

that's

the

reason

why

you

feel

tired
,

you

are

not

good

that

day
,

you

have

a

headache

and

all

these

symptoms
.

So

one

pathology

is

a

pathology

of

the

nervous

system
.

Speaker 1
30:16

Yeah
,

which

would

explain

why

there's

people

who

have

surgery

they

have

good

endometriosis

surgery
,

but

they

have

reoccurring

pain

or

persistent

pain

because

they

haven't

dealt

with

the

nervous

system

or

there's

something

else

going

on

with

the

nervous

system
.

Is

that

something

that

you

find

that

we

ignore

a

lot

of
,

and

that's

why

I

think

there's

risk

in

reoccurring

surgeries

by

not

addressing

that
.

Speaker 2
30:41

Yeah
,

as

you

know
,

in

the

past

when

I

performed

a

surgery

and

the

patient

had

still

pain

after
,

the

question

was

maybe

I

didn't

remove

everything

First
?

Secondly
,

oh
,

this

colleague

from

this

hospital

performed

a

surgery
.

He's

not

as

good

as

I

am
.

For

sure

he

was

missing

some

endometriosis
,

let

go

of

the

next

surgery
.

Or

maybe

I

was

thinking

oh
,

the

patient

is

getting

a

lot

of

hormonal

treatment
,

maybe

the

inside

effect

of

the

medical

hormonal

treatment

and

it's

true

that

if

patients

are

getting

a

lot

of

progesterone
,

one

of

the

main

side

effects

is

constipation
,

another

one

is

depression
.

So

it's

easy

to

say

the

patient

is

depressive

because

of

the

side

effect

of

the

hormonal

treatment
.

But

as

a

neuropelvologist

I

can

say

maybe

it's

because

of

the

overactivity

of

the

nervous

system
.

And

you

know

it's

very

frustrating

when

you

perform

a

laparoscopy

and

especially

you

will

not

find

a

lot

of

things
,

maybe

a

little

bit

endometriosis
.

You

have

to

do

your

job
.

You

have

to

convince

the

patient

that

you

found

endometriosis
,

because

today

patients

want

to

know

I

have

endometriosis
.

So

maybe

you

will

make

a

beautiful

picture

from

a

little

bit

endometriosis

and

then

after

the

procedure

you

will

say

yes
,

you

have

endometriosis
.

And

then

after

the

procedure

you

will

say

yes
,

you

have

endometriosis
.

If

you're

honest
,

you

will

say

I

don't

find

a

lot
.

Speaker 2
32:04

But

you

know
,

we

know

that

endometriosis
,

the

intensity

of

the

pain
,

is

not

correlated

to

how

many

endometriosis

you

see
.

And

it's

true
,

maybe

a

little

bit

endometriosis

will

induce

an

explosion

of

the

sympathetic

nerve

system
,

depending

also

on

the

situation

of

your

life

where

you

are
.

Suppose

you

want

to

get

pregnant

in

three

years
.

You

don't

get

pregnant
.

You

are

becoming

more

and

more

frustrated
,

nervous
.

That

will

increase

the

sympathetic

nerve

system

and

a

little

bit

of

endometriosis

will

increase

even

more

activity

of

the

sympathetic

inner

system
.

But

we

have

also

to

think

another

way
.

The

neuropedagogist's

way

is

to

say

we

did

a

good

surgery
.

Patient

has

still

the

same

pain
.

Maybe

I

made

the

wrong

diagnosis
.

She

has

endometriosis
.

But

the

main

reason

of

the

pain

maybe

is

not

the

endometriosis
.

It's

maybe

something

different
.

Speaker 1
33:01

Yeah
,

which

we've

talked

a

little

bit

about

this

offline

a

little

bit

but

the

fact

that

there's

a

lot

of

providers

that

lack

that

curiosity
,

that

they

look

inside

the

box

but

they

don't

look

outside

the

box
.

So

this

is

a

call

to

those

providers
,

to

any

provider

that

is

listening

it's

so

imperative

that

you

look

out
.

You

don't

even

create

a

box

to

look

out
,

you

have

a

base
,

but

then

you

explore

and

become

curious
,

which

is

why
,

when

we

were

talking
,

something

that

you

said

to

me

that

stuck

out

and

we'll

expound

on

this

a

little

bit

but

you

said

I

have

never

had

a

box
.

Why
?

Why

have

you

never

had

a

box
?

Why
,

why

have

you

never

had

a

box
?

And

this

is

where

we're

at

is

exploring

the

neuropelviology

aspect

of

endometriosis
.

Why

don't

we

have

this

box
?

The Vagus Nerve and Pain Management

Speaker 2
33:52

The

answer

is

maybe

because

I'm

a

French

guy
?

No
,

so

where

I

am
,

you

know
,

if

I

try

to

do

my

best

to

treat

a

patient
,

to

help

a

patient
,

and

I

fail
.

So

one

possibility

is

simply

to

say

what

I

said

I

had

the

wrong

diagnosis
.

I

have

to

think

out

of

the

box
.

But

the

reason

why

I

really

start

to

think

in

neuropalveology

is

nerve
.

It

was

a

little

bit

another

one
.

It's

not

because

I'm

a

French

guy
.

I

want

to

think

about

out

of

the

box
.

But

when

I

say

which

kind

of

mistake

I

was

doing
,

I

performed

a

great

surgery
,

I

was

very

proud

of

me
.

I

went

home
,

said

my

wife
,

wow
,

today

I

was

good
,

I

did

a

good

surgery
.

And

two

weeks

later

I

sent

my

patient

and

she

said

yeah
,

I

have

difficulty

to

pee
,

I

got

a

bladder

infection
.

What

I

have

to

do
?

Oh
,

you

have

to

use

a

bladder

catheter
.

Speaker 2
34:44

So

I

start

to

focus

my

attention

on

the

nerve

because

there

was

a

need

to

do

that
.

And

you

know
,

in

medicine

there

is

two

ways

to

see
.

You

can

see

the

positive
,

you

can

see

the

negative

and

in

my

opinion
,

if

you

want

to

help

patients
,

you

have

to

focus

your

attention

not

on

only

what

is

positive
.

But

you

have

to

try

to

understand

why

she

has

pain
.

You

have

to

look

for

problems
.

And

when

I

was

looking

for

why

it

is

like

that
,

that

is

the

point

where

I

understood

for

30

years
,

25

years
,

nobody

is

dealing

with

the

pelvic

nerve
.

I

would

suppose

we

have

colleagues
,

neurologists
,

that

know

everything

about

the

nerve
.

No
,

they

don't

know

about

the

pelvic

nerve
.

I

made

my

medical

study
.

I

never

heard

during

my

medical

study

anything

about

the

pelvic

nerve

because

it

was

difficult

for

everyone
.

There

are

so

much

nerves
.

Nobody

has

really

understood

or

had

the

understanding

how

really

it

worked
.

And

when

I

was

thinking
,

if

there

is

a

pathology

of

the

nerve
,

we

have

neurosurgeons
.

But

neurosurgeons

are

doing

brain

surgery
,

spinal

cord

surgery

or

maybe

surgery

on

the

nerve

which

they

can

access
,

but

neurosurgeons

are

not

trained

in

the

pelvis
.

Speaker 2
36:03

So

for

25

years

I

was

sitting

when

I'm

really

honest

I

will

give

you

a

little

bit

more

internal

personal

thoughts

my

wife

had

a

problem

after

vaginal

delivery
.

After

delivery

she

developed

severe

neurological

problems
.

So

we

went

together

to

neurologists
,

neurosurgeons
,

urologists
,

talk
,

nice

talk
,

but

finally

we

were

sitting

home

together

without

any

solution
.

And

that's

the

reason

why

I

said

okay
,

it's

a

big

black

box

in

medicine
.

Nobody

really

knows

what

is

going

on

in

this

pelvis

concerning

the

nerve
,

so

somebody

has

to

open

the

door
.

Speaker 2
36:44

If

you

talk

with

general

surgeons
,

visceral

surgeons

who

are

doing

rectum

resection

maybe

two
,

three

rectum

resections

per

day
,

every

day

the

nerves

are

a

few

millimeters

away

from

where

they

perform

the

surgery
.

But

most

of

the

general

surgeons

never

saw

the

sacral

nerve

root
.

So

general

surgeons

are

becoming

aware

about

the

parasympathetic

nerve
,

pelvic

nerves
,

and

starting

also

with

nerve

sparing

technique

is

a

good

thing
.

But

for

25

years

when

surgeons

came

in

my

world

for

the

boral

resection

I

said

never

I

will

do

that

because

you

will

cut

my

nerves
.

So

I

started

to

look

on

the

nerve

because

I

understood

there

is

a

need

to

do

that
.

Speaker 1
37:33

Yeah
,

which

is

why

you

know

it's

interesting
.

I

had

talked

to

some

doctors

gosh

a

while

back

talking

about

the

importance

of

understanding

neuropelviology
,

understanding

why

this

is

so

important

for

them

to

understand
,

and

they

didn't

understand

why

it

was

important

for

them

and

I

think

that

was

so

frustrating

as

a

patient

to

hear
.

I

don't

understand

why

that's

important
.

Well
,

it's

important

because

I

care

about

my

nerves
,

I

care

about

what's

happening

in

my

whole

body
,

but

I

shouldn't

be

the

one

that

has

more

information

about

how

this

all

plays

out
.

I

can't

help

myself
.

I'm

not

educated

to

do

that
,

but

maybe

I

am
.

Maybe

I

am

educated

to

do

that
.

But

I

think

that

one

of

the

things

that

was

frustrating

was

this

is

so

important

to

understand

for

them

Because

if

you

understand

the

basis

of

nerves

and

the

function

and

nerve

sparing
,

you

could

really

help

your

patient
.

Speaker 1
38:28

It's

about

patient

care
.

It's

about

patient

care
.

It's

about

caring

more

about

the

long

lasting

outcome

of

your

patient
,

not

just

the

here

and

now
.

And

I

think

it

was

really

frustrating

for

me

to

hear

that

and

I

was

a

little

discouraged
.

But

I

think

I'm

also

encouraged

by

the

fact

that

patients

can

make

an

impact

on

the

providers

by

saying

no
,

I

demand

more
.

I'm

not

going

to

settle

for

you

know

cutting

my

nerves

Like

ask

the

questions

Do

you

do

nerve

sparing
?

Speaker 1
38:58

How

do

you

do

nerve

sparing

Like
?

Those

are

questions

now

that

patients

I

feel

we

have

to

be

educated

on
,

and

that's

why

you

know
,

you

and

I

talking

about

this

today

is

so

important
,

because

I

feel

like

we're

at

this

crossroads

where

patients

are

becoming

more

savvy

and

they're

pushing

providers

to

become

more

engaged
.

Speaker 2
39:16

When

you

said

it's

frustrating

to

see

that

for

quite

a

lot

of

our

colleagues

they

don't

want

to

understand

neuropelviology
,

the

problem
.

I

don't

think

that

they

don't

want

to

understand

the

neuropelviology

thing

A

lot
.

I

don't

think

that

they

don't

want

to

understand

the

neuropelviology

thing
.

A

lot

of

colleagues

don't

know

what

it

is

neuropelviology
.

And

that

is

exactly

what

you

mentioned
.

Neuropelviology

is

not

just

nerve

sparing
,

it's

also

understanding

the

nerves
.

And

if

you

follow

me
,

you

saw

that

this

week

I

made

on

the

YouTube
.

I

met

on

an

education

on

endometriosis

and

the

topic

was

the

LUNA

technique
.

So

the

LUNA

technique

is

a

surgical

procedure

where

we

cut

what

we

call

the

sacro-uterine

ligament
.

So

you

cut

the

nerve

and

then

the

patient

has

less

pain
.

Yes
,

if

you

cut

the

nerve
,

the

patient

will

have

less

information

going

up

to

the

brain
.

Information
.

I

have

pain
,

but

you

remember

what

I

say
.

The

nerves

are

working

in

both

directions
.

So

you

cannot

just

cut

the

nerves

that

bring

the

information

of

pain

to

the

brain
.

You

will

cut

also

nerve

going

to

the

vagina
,

to

the

uterus
.

And

when

we

think

about

the

sympathetic

or

the

parasympathetic

nerve

system
,

the

parasympathetic

nerve

system
,

just

in

terms

of

fertility
,

it

is

in

charge

of

the

ovulation
,

it

is

in

charge

of

the

motion

of

the

tube
.

It

is

in

charge

of

the

motion

of

the

uterus
.

It

is

in

charge

of

the

motion

of

the

uterus
.

He's

in

charge

of

the

opening

of

the

cervix
.

He's

even

in

charge

of

the

motility

of

the

spermatozoid

in

men
.

So

suppose

you

perform

a

Luna

technique

and

you

cut

a

lot

of

parasympathetic

nerve

system
.

Maybe

you

will

have

a

negative

impact

on

the

fertility

of

the

patient

because

you

will

maybe

reduce

the

chance

to

get

ovulation
,

you

will

reduce

the

motility

of

the

tube
,

maybe

the

patient

will

develop

an

increased

risk

for

ectopic

pregnancy

and

maybe

it

will

change

the

mobility

of

the

uterus
.

Speaker 2
41:27

You

know

that

is

something

we

know

when

we're

performing

surgery

for

deep

endometriosis

of

what

we

call

the

sacro-uterine

ligament
,

then

you

cannot

spare

all

the

nerve
.

You

have

to

remove

the

disease

and

we

know

that

in

patients

when

we

perform

surgery

for

deep

endometriosis

it

will

be

more

difficult

for

the

patient

to

get

a

vaginal

delivery

because

of

the

cutting

of

the

nerve
.

In

a

lot

of

these

patients

after

previous

deep

endometrial

surgery

there

will

develop

a

dysfunction

of

the

cervix

and

the

cervix

will

not

get

open
.

And

I

think

a

lot

of

patients

will

recognize

themselves

when

I

said

open
.

And

I

think

a

lot

of

patients

will

recognize

themselves

when

I

said

you

got

a

surgery

for

deep

endometriosis
,

you

got

pregnant

and

then

you

were

staying

two
,

three

days

in

obstetric

department
.

They

tried

to

give

you

a

lot

of

medication

to

open

the

cervix
.

It

didn't

happen
.

And

finally

you

got

a

C-section

because

the

cervix

didn't

get

open

because

of

the

cutting

of

some

of

the

parasympathetic

nerve

of

the

cervix
.

So

you

see

how

the

nerve

are

linked

to

everything
,

to

everything
.

Speaker 1
42:41

Yes
,

and

this

is

why

it's

so

important

for

people

to

learn

about

this
.

This

is

why

not

even

just

the

provider
,

but

the

patient

to

understand

because

if

you've

had

surgery

in

the

past

to

understand

why

some

of

these

struggles

are

occurring
,

I

think

it's

so

important
.

I

wish

I

would

have

known

some

of

these

things

prior

to

some

of

my

surgeries
,

but

hindsight

is

20-20

and

I'm

moving

forward
,

knowing

this

and

helping

others
,

and

that's

why

I'm

doing

what

I'm

doing
,

because

of

things

like

this
.

The

more

we

learn
,

the

more

educated

we

are
,

the

better

decisions

we

can

make
,

the

better

we

can

advance

healthcare

for

women
,

for

endometriosis

patients
,

for

all

those

patients

who

are

dealing

with

other

chronic

illnesses
,

to

help

us

navigate

life

that

is

more

fulfilling

and

have

a

better

quality

of

life
.

That

is

the

whole

message

here
,

right
,

yeah
?

Speaker 2
43:30

You

know
,

I

think

you

cannot

say

we

need

education

for

the

doctor

and

not

of

the

patient
,

or

contrary
,

you

need

education

on

both
.

We

are

partners

when

we

are

dealing

with

your

body
,

even

more

when

you're

in

the

war
,

you

are

on

anesthesia
,

you

have

to

trust

us
,

we

have

to

trust

you

as

well
.

We

have

to

partner
,

to

be

partner

on

that
.

And

you

know

when

I

start

for

for

30

years

with

endometriosis
,

we

know

as

a

doctor

the

name
,

but

we

didn't

have

a

lot

of

knowledge

about

endometriosis

was

for

30

years

a

benign

disease

which

is

painful
,

that's

it
.

The

wait

until

the

patient

will

get

one
,

two

babies

and

then

you

will

remove

the

uterus
,

that

was

endometriosis
.

So

we

have

to

educate

ourselves
.

But

I

think

the

key

which

really

changed

the

story

of

the

endometriosis

over

the

last

20

years

was

the

education

of

the

patient
.

And

you

know

that

is

a

shame
,

but

when

I

was

for

two
,

three

days

in

Bangkok
,

we

were

talking

about

deep

endometriosis

and

rectum

resection

and

then

we

were

talking
,

wow
,

we

got

a

great

evolution

over

the

last

20

years
.

We

started

to

perform

ball

resection
,

now

we

have

shaving
,

now

we

have

discoid

resection
,

now

we

have

robotic

surgery
.

We

have

such

an

improvement
.

But

if

you

see

the

data

out

of

the

gynecological

box

and

you

go

to

the

field

of

the

general

surgeon

in

your

country
,

in

the

United

States
,

you

have

the

College

of

Surgeons

I

think

it

was

2015,
.

They

performed

a

paper
,

a

big

paper
,

about

the

situation

of

bowel

resection

for

endometriosis

in

the

United

States

and

definitively
,

the

number

of

patients

who

are

getting

this

procedure

increase

in

the

United

States
.

And

in

this

paper
,

in

this

study
,

if

you

see
,

the

main

age

is

43
.

And

then

when

I'm

seeing

that
,

I

said
,

wow
,

I

don't

understand
.

Because

endometriosis
,

the

rectum
,

take

10

years

to

develop
.

So

if

you

are

doing

more

and

more

borrower

section

for

deep

endometriosis
,

the

rectum

takes

10

years

to

develop
.

So

if

you

are

doing

more

and

more

borrower

section

for

deep

endometriosis
,

because

we

are

doing

less

and

less

early

diagnosis

and

that

is

a

big

mistake

on

our

side
.

And

secondly
,

you

know

I

always

learn
,

or

my

experience

is

the

more

the

patient

will

go

in

direction

of

the

postmenopause

don't

be

that

aggressive

the

more

the

patient

will

go

in

direction

of

the

postmenopause
,

don't

be

that

aggressive
.

So

usually

in

patients

more

than

40
,

don't

try

to

do

borrower

section
.

So

if

you

see

this

study

from

the

general

surgeon
,

you

see

more

and

more

borrower

section

and

the

mean

age

is

43
.

I

think

that

means

some

patient

with

78
,

48
,

49

are

getting

a

bowel

resection
.

That

is

insane
.

That

is

a

problem
.

We

need

education

of

doctor
,

but

patient

need

education

as

well
.

Speaker 2
46:47

If

something

is

wrong

and

you

have

the

feeling

maybe

I

could

have

such

kind

of

things

and

the

doctor

said
,

oh
,

you

have

deep

endometriosis
.

But

you

know
,

bowel

surgery

is

quite

dangerous
.

Wait

and

see
.

No
,

don't

wait

and

see
,

because

surgery

is

like

a

vaccination
.

Beyond Comorbidities: One Nervous System

Speaker 2
47:05

You

have

to

remove

the

deep

endometriosis

before

it

starts

to

grow

within

the

rectum

and

that

is

my

main

message
.

If

it's

deep

endometriosis
,

as

gynecologists

we

have

not

to

wait
,

we

have

to

do

before

it

will

induce

further

damage

and

that

is

really

a

problem

in

gynecology
.

Normally
,

if

we

are

able

to

increase

such

an

awareness
,

normally

the

number
,

the

incidence

of

bowel

resection

should

have

to

decrease

and

it

increases
.

So

something

is

going

wrong
.

Speaker 1
47:43

Yeah
,

well
,

I

think

too

teens

with

endometriosis

are

being

dismissed

as

it's

not

bad

enough

yet

or

wait

until

you're

older
.

I

mean

the

things

that

I

hear
,

and

there's

a

lot

of

providers

that

are

scared

to

even

touch

teens

with

endometriosis

Obviously

not

the

expert

side

of

things
,

but

the

general

GYN
,

who

don't

typically

do

just

endometriosis
.

They're

afraid

to

send

teens

for

surgery

here

a

lot

of

times
.

Speaker 2
48:08

But

they

probably

collect

to

train

in

this

surgery

or

train

to

manage

endometriosis

Right
.

It

has

not

to

be

a

question

of

ego
,

but

once

again

we

have

to

be

partners

all

together
.

Speaker 1
48:23

Yeah
,

and

I

will

tell

you
,

as

a

patient
,

it

can

be

very

hard

to

continue

to

try

to

convince

your

doctors

to

keep

exploring
.

And

that's

where

you

see

the

fatigue

of

patients
,

where

you

see

the

patients

are

like

I

don't

know

what

else

I

can

do
,

and

they're

seeing
,

you

know

six
,

seven
,

eight
,

nine
,

ten

doctors

before

someone

actually

says

I

believe

you
,

let's

do

something

about

this
,

let's

explore

it
.

We

have

to

keep

going
.

As

a

patient
,

but

as

providers
,

just

sitting

and

listening
,

you

can

tell

a

lot
.

You

don't

even

have

to

do

a

pelvic

exam

to

hear

their

pain
.

Speaker 1
49:05

It's

just

sitting

and

listening

and

looking
.

Speaker 2
49:09

And

looking

the

face

like

we

learned

today
.

Speaker 1
49:13

Yeah
,

and

you

know

it's

interesting
.

So

I'm

going

to

tell

you

this

because
,

as

a

patient
,

this

is

what

we've

talked

about

A

lot

of

times

when

I

go

to

see

a

doctor

to

be

believed
,

I

won't

wear

makeup
,

I

will

look

a

lot

more

rough
,

I

won't

put

myself

together
,

because

then

I

feel

like

they

will

believe

me

more

than

if

I'm

put

together
,

and

that's

a

sad

statement
.

Speaker 2
49:36

But

you

know
,

I

think

it's

not

just

a

question

of

belief
,

it's

also

a

problem

with

the

medical

system
.

Speaker 2
49:43

So

I

don't

know

how

it

is

in

the

United

States
,

but

if

you're

in

Switzerland

you

will

be

paid

by

the

insurance

for

consultation

from

15

minutes
,

no

more
,

and

to

deal

with

patients

with

endometriosis

sometimes

it

takes

one

hour
.

Speaker 2
49:57

But

as

a

doctor
,

if

you

are

doing

your

job

and

suppose

you

are

an

expert

in

endometriosis

and

you

see

every

day

really

big

cases

of

endometriosis
,

at

the

end

of

the

month

you

will

be

a

poor

doctor
.

Because

if

you

see

only

five
,

six

patients

per

day

and

not

what

the

insurance

expect

from

you

maybe

20
,

30

patients

per

day

so

that

is

really

a

problem
.

The

doctor

who

will

perform

a

good

job

you

know

what

I

mean

is

not

fair

and

that's

the

reason

why

I

like

very

much

the

system
,

for

example
,

like

in

Denmark
,

where

you

have

really

center

of

endometriosis

and

then

they're

dealing

just

with

endometriosis
.

He's

calling

it
,

and

I

think

that

is

a

good

idea
.

I

don't

think

that

everybody

has

to

be

an

expert

in

endometriosis

or

an

expert

in

neuropelviology
,

but

at

least

in

diagnosis
,

or

an

expert

in

neuropelviology
,

but

at

least

in

diagnosis
.

Speaker 1
50:50

Right
,

and

at

least

a

basic

understanding
,

I

think
,

is

helpful
.

Right
,

understanding

the

anatomy

is

helpful
.

Understanding

the

role

that

nerves

play

in

our

body
.

I'm

going

to

shift

gears

a

little

bit
,

because

this

is

why

I

think

understanding

the

nerves

is

so

important
.

We've

talked

about

the

role

they

play

for

endometriosis
,

but

you're

exploring

something

more

and

this

is

why

I

want

to

just

drive

home

a

little

bit

more

how

important

nerves

are

to

our

body
,

because

you're

putting

the

connection

between

nerves

and

the

spinal

cord
.

Can

you

explain

why

this

is

so

important
,

why

the

research

and

how

you're

coming

about

this
?

Because

I

think

it

will

help

a

lot

of

us

understand

the

role

that

nerves

play

beyond

endometriosis
.

Speaker 2
51:36

So

if

you

want

to

explain

to

me

a

little

bit

more

the

neuropalveology

beyond

the

gynecology
,

yes
,

in

neuropalveology

we

are

dealing

with

tumor

of

the

nerve
,

we

are

dealing

with

entrapment

of

the

nerve

and

there

is

one

condition

you

mentioned
.

It

is

spinal

cord

injury
.

Spinal

cord

people
.

You

have

the

damage

at

the

level

of

the

spinal

cord

but

the

nerves

which

control

the

legs

in

the

lower

part

of

the

spinal

cord
,

so

these

nerves

are

not

controlled

anymore

by

the

brain
,

but

they

are

still

working
.

And

that's

the

reason

why

a

lot

of

paraplegic

or

tetraplegic

patients

have

what

we

call

spasticity
.

Spasticity
,

that

means

the

nerves

below

the

spinal

cord

lesion

is

still

working
,

but

not

the

proper

way
.

They

are

not

getting

the

right

information
.

And

that's

the

reason

why
,

in

the

field

of

neuropalveology
,

I

developed

what

we

call

the

LION

procedure
.

Lion

procedure

is

a

technique
,

how

to

bring

stimulation

electrode

to

the

pelvic

nerve
,

so

the

pelvic

nerve

for

the

bladder
,

for

the

genital

organ
,

for

the

legs
,

so

for

the

capability

of

staying

up

and

walking
.

And

that

is

one

of

my

work

as

a

neuropalveologist
.

I'm

doing

surgery

in

men

despite

I'm

a

gynecologist

because

most

of

the

spinal

cord

injury

people

are

men

due

to

traffic

accident

and

I

bring

in

electrodes

to

the

nerve

to

recover

a

capability

of

staying

up

and

to

work

with

crutches
.

We

have

now

more

or

less

150

patients
.

We

perform

surgery

and

70

persons

are

able

to

walk

at

least

10

meters
,

the

best

one

even

2.5

kilometers
.

Speaker 2
53:20

So

you

see

that

that

is

neuropalveology

and

that

is

the

reason

a

lot

of

gynecologists

think

neuropalveology

is

not

just

nerve

sparing
.

No
,

no
,

no
,

that

is

just

the

small

door

we

open

for

30

years
,

for

20

years
.

Neuropalveology

is

much

more

than

that
.

It's

the

treatment

of

children

with

penibifida
.

It's

the

treatment

of

children

with

peniphyda
.

It's

the

treatment

of

people

with

multiple

sclerosis
,

with

polyneuropathy
,

all

the

pathology

of

the

pelvic

nerves
.

And

of

course

we

have

to

discover

a

lot

because

we

are

not

at

the

end

station
.

I

think

the

knowledge

we

have

about

the

functionality

of

the

pelvic

nerve

today

will

probably

change

a

lot

in

10

years
,

but

for

that

we

have

to

look

on

these

nerves
.

Speaker 1
54:09

It'll

change

because

of

people

like

you

who

are

willing

to

explore

it
,

and

I

think

there's

doctors

coming

to

your

courses

and

learning

more

about

it
,

and

these

are

the

changing

faces

of

neuropelviology
.

They're

going

to

be

the

change

in

neuropelviology
,

but

not

just

neuropelviology
,

I

think
,

across

the

board

for

medicine
.

I

think

these

are

the

very

curious

doctors

who

are

going

to

push

boundaries

and

push

back

on

the

systems

that

have

kind

of

put

them

in

a

box
,

and

I'm

really

excited

to

see

that
.

Speaker 2
54:47

These

doctors

are

like

my

metastasis
.

You

know

If

you

will

talk
,

they're

in

oncology
,

they

are

metastasis

and

our

work

tells

them
.

You

know
,

when

you

have

a

patient

affected

by

a

cancer
,

usually

not

the

primary

cancer

will

kill

the

patient
,

but

the

metastasis
,

and

that

is

exactly

the

point
.

I

don't

think

that

I

will

see

neuropelviology

becoming

really

a

university

sociality
,

but

it

will
,

my

metastasis
.

They

will

do

that
,

they

will

achieve

that
.

They

will

see

that

the

neuropelviology

will

be

behind

gynecology

urology
,

another

recognized

specialty

in

the

pelvis

surgery
.

Speaker 1
55:25

Yeah
,

it's

exciting

to

see
.

I

was

just

at

the

endometriosis

summit

and

met

a

lot

of

these

doctors

and

they

are

fantastic

and

they

only

speak

of

the

utmost

respect

for

you

and

the

work

that

you're

doing
.

But

it's

so

interesting

to

see

the

things

that

they

are

exploring

and

looking

at

and

challenging

each

other

with

and

challenging

other

providers

with
,

and

talking

to

the

patients

and

educating

the

patients

and

they

are

a

class

all

their

own

and

they

are

fantastic

and

just

great

humans
.

They're

not

just

great

providers
,

they're

great

humans

Some

of

the

best
.

And

they

have

humans
.

They're

not

just

great

providers
,

they

are

great

humans
,

some

of

the

best
.

Speaker 2
56:02

And

they

have

time
.

They

have

time

and

you

know
,

when

you're

30

and

you

discover

such

a

world

like

neuropulmonary

biology
,

it's

fantastic
.

You

open

the

door

from

a

mystery
.

It's

wonderful

when

I

see

some

of

my

young

fellow

from

Sao

Paulo

or

from

Mumbai
.

These

young

doctors
,

they

are

30
,

35
,

something

like

that
.

That

means

they

have

still

30

years

to

explore

the

mystery

of

the

neuropelvary
.

It's

fantastic
.

I'm

a

little

bit

jealous
.

I

open

the

door
.

They

will

go

inside
,

but

that's

the

way

how

it

works
.

Speaker 1
56:41

Yeah
,

and

that's

how

it

should

work

right
.

That's

how

we

should

continue

paving

the

way

for

future

generations
,

and

they

have

to

be

better

than

I

was
.

Speaker 2
56:46

That

is

the

point
.

A

fellow

has

to

become

better

than

the

master
.

It

is

like

that
.

Otherwise

I

would

do

something

wrong
.

Speaker 1
56:55

I

love

that
.

I

love

that

you

see

it

that

way
,

that

it's

not

about

the

ego
,

it's

about

the

continuing

of

that

education
,

and

that's

what's

going

to

change
.

Speaker 2
57:04

Yeah
,

but

that

is

clear
.

Otherwise

the

day

I

will

die

or

get

retired
,

neuropathology

will

disappear

with

me
.

No
,

I

don't

want

that
.

The

young

guy
.

They

will

have

to

promote

the

neuropathology

in

the

rest

of

the

world
,

and

really

with

Aizen

and

the

neuropathology

in

the

rest

of

the

world

and

really

with

Eisen

Eisen

is

the

internal

society

of

neuropathology
.

Really

we

are

succeeding

very

slowly
,

quite

more

or

less

in

the

shadow
.

We

are

not

going

on

the

street

and

making

a

lot

of

noise
,

but

now

we

have

more

and

more

colleagues

in

South

America
,

a

few

colleagues

in

the

United

States

in

South

America
,

a

few

colleagues

in

the

United

States
.

Now

we

are

becoming

more

and

more

in

India
,

in

Asia
,

in

Middle

East
,

so

everywhere

you

have

small

young

guys

who

start

to

let

grow

the

neuropathology

in

their

own

country

and

that

is

beautiful
.

It's

amazing

to

see

that
.

Speaker 1
57:57

Yeah
,

you

know
,

talking

to

Dr

Ming

is

always

like

one

of

my

favorite

things

to

do
.

He's

one

of

my

favorite

humans

to

talk

to

because

I

learn

from

five

minutes

of

sitting

down

with

him
,

every

single

time
,

his

wisdom

and

his

humility

behind

it
.

It

just

every

single

time

one

of

the

best

guys

out

there

in

my

opinion
,

and

it's

always

fun

to

just

sit

and

hang

out

with

them
,

which

I

get

the

privilege

of

doing

when

we're

at

the

summit
.

So

it's

true
,

they're

great

people

and

curious

and

I

love

that
.

They

look

circumspect
.

They

don't

look

straight

ahead

in

this

narrow

box
.

Very

circumspect
,

they're

always

looking

around

Why Surgery Isn't Always the Answer

Speaker 1
58:37

.

They're

looking

at

seeing

correlations
,

they're

looking

at

different

ways

of

addressing

not

only

the

disease

but

diseases

that

like

to

accompany

endometriosis
.

It's

fascinating

every

single

time

and

I

love

it
.

Speaker 2
58:50

That

is

a

beauty

of

the

life

to

have

an

open

mind

in

all

direction

of

the

life
,

not

just

in

medicine
.

You

have

to

be

curious

in

life
.

I

remember

a

very

nice

word

from

Einstein
.

Einstein

said

innovation
,

or

vision
,

is

much

more

important

than

knowledge
.

And

now

a

vision

is

born

from

curiosity
.

Speaker 1
59:15

Yes
,

I

love

that

and

I

think

that

is

like

my

life

motto

to

always

be

curious

about

what's

next

and

what

I

can

learn

more

from

Looking

forward

and

exploring

curiosity
.

What

are

you

excited

for

that

is

making

you

more

curious
?

Speaker 2
59:35

You

know
,

when

I

was

a

young

boy

I

was

reading

Jules

Verne

and

Jules

Verne
.

When

I

was

a

young

boy

I

was

reading

Jules

Verne

and

Jules

Verne
.

He

sent

the

people

on

the

moon
.

So

it

was

a

curiosity

of

that

time
.

Today

it's

reality
.

For

me
,

my

curiosity

is

what

I

call

in-body

stimulation
.

Future

we'll

try

to
,

to

treat
,

so

to

avoid

disease

and

maybe

even

to

treat

a

lot

of

disease

by

using

neuromodulation

of

the

autoimmune

system
.

And

that

is

exactly

the

point
.

You

know
,

I

mentioned

you

uh

to

to

have

stimulation

here

of

the

nervous

vagus

in

heart
.

I

told

you
,

10

minutes

in

the

morning
,

10

minutes

in

the

evening
,

but

maybe

it

would

be

nice

to

have

a

stimulation

within

the

body

that

make

you

happy

all

the

day
,

every

day
,

all

the

time
.

I'm

quite

sure

that

in

the

future
,

in

maybe

10

years
,

20

years
,

we

will

have

electronic

in

the

body
.

You

know
,

10

years
,

20

years

we

will

have

electronics

in

the

body
.

You

know
,

for

20
,

30

years
,

when

I

was

a

young

boy

it

was

a

3

million

guy
.

You

know
,

it

was

in

an

American

movie

where

guys

got

some

electronics

in

the

body
.

He

was

able

to

run

more

faster
,

he

was

able

to

do

everything

much

better

than

with

a

normal

body

and

I

think

really

we

will

go

in

this

direction
.

I

don't

think

even

I'm

sure

we'll

go

in

this

direction

because

last

year

we

had

a

congress

of

the

AISON

in

Paris

and

we

invited

a

guy
,

an

engineer
,

dealing

with

such

kind

of

a

device

which

we

can

bring

inside

the

body

and

he

said

we

have

already

all

these

devices
.

It's

just

a

question

when

we'll

get

an

etichomite

and

to

start

to

bring

such

kind

of

device

in

the

body
.

So

suppose

I

have

the

opportunity

to

have

a

continuous

stimulation

of

the

vagus

nerve

somewhere

in

your

body
.

The

vagus

nerve

is

in

the

abdominal

cavity
.

That

would

be

easy

to

bring

a

device

there

and

to

stimulate
.

I

will

make

you

happy
,

you

will

have

less

problem
,

you

will

maybe

get

much

easier

pregnant
,

you

will

have

less

pain

during

men

bleeding
.

So

I

think

it

will

go

in

this

direction
.

Speaker 2
1:01:57

And

you

know
,

I

think

the

neuromodulation

will

have

also

an

impact

in

endometriosis
.

Because

when

you

have

endometriosis
,

endometriosis

and

use

a

lot

of

adhesion

in

the

pelvis
,

because

endometriosis

is

an

inflammatory

disease

within

the

pelvis

and

there

is

something

what

we

call

TNF

factor
,

tumor

necrosis

factor
.

They

are

factors

which

belong

to

the

inflammation

disease

within

the

pelvis

and

there

is

clear

evidence

that

with

stimulation

of

the

vagus

nerve

we

have

an

anti-TNF

factor

action
,

so

we

can

decrease

inflammation

within

the

pelvis

by

using

the

vagus

nerve

stimulation
.

And

from

the

medical

aspect
,

actually

there

are

some

medication

pills

which

will

come

on

the

market

to

decrease

the

level

of

the

TNF
,

of

the

tumor

necrosis

factor
.

My

thought

would

be

why

not

to

do

that

with

neuromodulation
,

which

will

have

much

less

side

effect
,

Right

and

maybe

in

the

future
?

And

that's

the

reason

why

it

would

be

nice
.

Speaker 2
1:03:11

I

think

with

stimulation

of

the

transauricular

stimulation

I

don't

say

that

we

would

be

maybe

able

to

treat

endometriosis

and

maybe

to

avoid

surgery
,

but

maybe

decrease

the

level

of

pain
.

And

that

is

also

something

Because

when

you

take

a

hormonal

treatment

or

painkiller

you

have

no

impact

on

the

activity

of

the

endometriosis
.

You

decrease

the

pain

level
.

Speaker 1
1:03:36

Yes
,

decrease

that

fight

or

flight

Exactly
,

and

maybe

we

can

decrease

not

only

the

pain

but

the

amount

of

endometriosis

that

invades

the

body
.

Speaker 2
1:03:49

Absolutely
,

absolutely
.

But

because

there

is

clearly

scientific

evidence

that

by

stimulation

of

the

vagus

nerve

you

will

increase

the

immunity
,

the

immune

system
,

and

endometriosis

may

be

a

kind

of

immune

dysregulation
.

White

cells

from

the

uterus

get

the

capability

to

grow

within

the

abdominal

cavity
,

on

the

peritoneum

or

somewhere
,

maybe

because

locally

there

is

a

depression

of

the

immune

system

that

allows

the

cells

to

develop

and

to

grow

at

that

location
.

Maybe

with

an

increasing

of

the

activity

of

the

parasympathetic

nerve

system

we

will

decrease

the

ability

of

this

nerve

to

grow

to

implant

within

the

abdominal

cavities
.

So

why

not
?

Why

not
?

That's

the

Thinking Outside the Box in Medicine

Speaker 2
1:04:40

future
,

absolutely
.

Speaker 1
1:04:42

Well
,

and

it's
,

I

mean
,

gosh

you

think

about
.

Even

you

know

you

mentioned

this

earlier

and

I'm

kind

of

backpedaling

a

little

bit
,

but

you

mentioned
,

like

the

pregnancy

is

murder

when

we're

in

such
,

you

know
,

high

fight

or

flight
.

Speaker 1
1:04:55

That's

why

you

know

it's

interesting

that

I

see

a

bunch

of

people

who
,

during

their

adoption

process

or

during
,

you

know
,

wanting

to
,

maybe

they're

going

to

have

surgery

for

a

hysterectomy

and

so

they've

kind

of

relaxed

and

all

of

a

sudden

they're

pregnant

you

know
,

and

I

think

that's

only

like

that's

not

happened

for

everyone

and

I

don't

want

to

put

that

across

the

board
,

but

what

I'm

saying

is

there's

something

to

down-regulating

that

sympathetic

system

and

up-regulating

that

parasympathetic

system

of

rest

and

digest
,

taking

a

breath
,

and

that's

what

you

know
.

We

talk

about

the

breath

work
,

we

talk

about

the

stimulation
,

and

this

all

plays

a

part

in

how

we

manage

this

disease
,

and

I

think

a

lot

of

people

are

always

curious

as

to

how

can

I

help

manage

my

endometriosis
,

how

can

I

help

manage

my

pain
.

This

is

an

avenue

which

everyone

can

explore
.

Speaker 2
1:05:48

It's

not

just

surgical
.

Speaker 1
1:05:49

It's

a

practical

way

for

us

to

be

able

to

manage

pain
,

to

manage

potential

increase

in

the

endometriosis

within

our

body
.

You

know

the

stimulation
,

the

breath
,

work
,

the

food
,

the

stress

all

of

these

things

play

a

part

in

that

so

effect
.

Speaker 2
1:06:08

You

know

there

is

a

simple

thing

when

is

the

best

time

in

life

of

a

woman

to

get

pregnant
?

In

the

past
,

always
,

everybody

said

the

best

way

is

to

get

married

and

to

go

on

honeymoon
.

Why

honeymoon
?

Because

you

have

an

overactivity

of

the

parasympathetic

nerve

system
.

Your

body

is

full

of

butterflies
,

you

are

happy
,

happy

and

happy
.

That

increases

the

parasympathetic

nerve

system
.

And

in

the

Pons

old

lady

always

says

the

best

way

to

get

pregnant

is

to

go

on

honeymoon
.

Try

to

get

pregnant

is

to

go

on

honeymoon
.

Try

to

get

pregnant

in

holidays
.

Yeah
,

because

you

have

no

activity

of

the

past

path

sympathetic

nervous

system
.

So

science

is

coming

to

reality

what

people

in

the

plants

were

talking
.

So

it's

not

out

of

the

blue
.

It

was

experience

to

see
.

When

you're

happy

you're

getting

much

easier

pregnant

than

when

you're

unhappy
.

Speaker 1
1:07:03

And

exactly
.

Speaker 2
1:07:03

to

change

these

things

is

not

like

to

take

a

normal

adrenaline
,

take

a

pill

or

a

surgery
.

Everybody

can

try

that

without

side

effects
.

Stimulation

of

the

vagus

nerve

is

an

easy

thing
.

You

found

that

everywhere

on

the

internet
.

It's

easy

easy

thing
.

Speaker 1
1:07:22

You

found

that

everywhere

on

the

internet
.

It's

easy

yeah
,

it

is
,

and

we

have

to

make

time

for

it
,

and

that

is

one

of

the

things

that

I

feel

like
.

A

lot

of

us

are

constantly

trying

to

find

solutions
,

trying

to

find

ways

to

cope

and

manage
.

Sometimes

it's

being

quiet

or

stimulating

in

other

ways
,

and

I

have

found

myself

to

struggle

with

this

a

lot

because

I'm

a

busy

body
,

but

my

busy

body

gets

me

in

trouble

because

then

it

puts

me

out

for

a

couple

of

days
.

So

I

think

it's

important

after

time
,

learning

about

this

that's

something

that

I

have

really

taken

to

heart

is

how

do

I

do

this

practically

in

my

life
?

Because

we

talk

about

endometriosis

being

a

whole

body

disease

and

a

whole

life

disease
.

It

truly

is
.

You

can

help

your

whole

body

and

you

will

help

the

whole

disease
.

Speaker 2
1:08:07

Yeah
,

and

don't

say

that

by

stimulating

the

parasympathetic

nerve

maybe

you

will

treat

your

endometriosis
,

but

maybe

you

will

make

your

life

a

little

bit

easier

and

the

life

of

your

family

as

well
.

Speaker 1
1:08:21

Yeah
.

Speaker 2
1:08:24

Which

will

make

it

easier
.

Speaker 1
1:08:26

Yeah
,

I

love

that
.

I

love

that

this

is

a

practical

tool

Like
.

You're

not

just

a

surgeon
,

you're

more

like

a

therapist

at

this

point
.

You're

a

life

coach
.

That's

what

you

are
.

You're

a

life

coach
.

You're

a

life

coach
.

That's

what

you

are
.

You're

a

life

coach
.

Professor

Possever
,

thank

you

so

much

for

taking

the

time

to

sit

down

with

me
.

I

am

leaving

with

my

cup

full

today

just

talking

about

this

and

learning

from

you
.

I'm

excited

to

see

where

neuropelviology

goes
.

I'm

excited

to

see

where

you're

able

to

have

your

fellows

go

and

to

teach

them

to

branch

out
.

Much

like

a

nerve

if

you

ignite

it

one

place
,

it'll

spread

out

in

other

places
,

and

that

is

where

your

wisdom

and

passion

and

knowledge

go
.

So

I

just

appreciate

everything

that

you're

doing

for

so

many

people
,

but

for

sitting

down

and

talking

about

this

and

bringing

this

to

light

is

going

to

make

such

a

huge

impact

for

so

many
.

So

thank

you

so

much

for

doing

that
.

Speaker 2
1:09:21

I

have

to

thank

you

for

this

opportunity

and

your

kindness
,

because

it's

not

easy
.

It's

not

easy
,

my

first

podcast
,

but

it

makes

me

happy

If

we

can

do

and
,

by

the

truth
,

that

is

what

we

call

the

Hippocrates

Oak

to

do

everything

for

my

patient
.

I

promise

that

and

what

we

are

doing

here

is

promoting

educational

patient
.

Patient

have

to

know

their

own

body

and

if

they

know

their

own

body
,

they

will

even

better

know

which

doctor

is

the

right

one

to

help

them

or

not
.

Speaker 1
1:09:51

Yes
,

it's

so

true

Knowledge

is

power
.

Speaker 2
1:09:54

Knowledge

is

power
.

Speaker 1
1:09:55

Yeah
,

absolutely
.

Well
,

until

next

time
.

Everyone

continue

advocating

for

you

and

for

others
.

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